Erythrocyte Acetylcholinesterase

Cholinesterases are enzymes that help regulate the normal functioning of the nervous system. They break down a neurotransmitter called acetylcholine so that it does not cause over-stimulation of muscles. However, certain chemicals such as pesticides – if they find a way into our body – can interfere with the functioning of cholinesterase, leading to breathing difficulty, and muscle weakness.

Looking for the meaning of Cholinesterase Test, or its results or why is Cholinesterase Test done, or what is the cost of Cholinesterase Test? Look no further, as this article provides all this information about Cholinesterase Test including normal range, online booking and more.

Why get tested:

• To determine if you have been exposed and / or poisoned by certain organophosphate chemicals found in pesticides; to control cholinesterase levels if you work with pesticides
• Sometimes to identify people with inherited pseudocholinesterase deficiency before they are given anesthesia with the muscle relaxant succinylcholine or to help determine the cause of prolonged apnea after surgical anesthesia.

When to get tested:

• When you have symptoms of pesticide poisoning or on a regular basis when you are at risk of exposure to organophosphates, such as through work in the agricultural industry and / or frequent use of organophosphate insecticides.
• When you or a close relative have experienced prolonged apnea and muscle paralysis after using the drug succinylcholine for a surgical operation.

Sample and Precautions:

Specimen: 2 ML (0.5 ML Min.) Serum From 1 SST.
Preparations: No Special Preparation Required.
Precautions:
Avoid hemolysis.
Avoid repeated freezing and thawing.
Pregnancy decreases test value.
Drugs that may cause a decrease in the test value is atropine, caffeine, codeine, morphine, oral contraceptives, theophylline, quinidine, estrogen, and vitamin K.

Normal Values:

Source 1:

Serum cholinesterase =  8 to 18 units/mL

Source 1

Male: 4.62 – 11.50 ku/L
Female: 3.93 – 10.80 lu/L

Source 2

Normal Values: 1355 – 3299 IU/L

Source 4:

Male:

1 day to 5 years: Not established
6 to 17 years: 1396−3282 U/L
18 to 70 years: 1801−3537 U/L
71 years and older: 903−2964 U/L

Female:

1 day to 1 year: Not established
2 to 12 years: 1649−2940 U/L
13 to 50 years: 1247−2978 U/L
51 to 80 years: 1355−3299 U/L
81 years and older: Not established

Increased level is seen in:

• Nephrosis.
• Diabetes mellitus.
• Hyperlipidemia

Decreased Level is seen in:

• poisoning with organophosphate insecticide.
• Liver diseases like hepatitis.
• Cirrhosis with ascites or jaundice.
• Metastatic carcinoma.
• Obstructive jaundice.
• Congestive heart failure.
• Before you receive anesthesia with succinylcholine, which may be given before certain procedures or treatments, including electroconvulsive therapy (ECT).
• In the condition with low serum albumins like malnutrition, anemia, infections, Dermatomyositis, Acute MI, and liver diseases.

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